essential_drug

Providing essential drugs that support healthcare professionals and patients.

Yoshindo Holdings aims to become a technology-oriented company that contributes to the advancement of healthcare as an Essential Drug Pharma provider. We develop and provide a stable supply of essential pharmaceuticals for medical practice, including infusion products, injectable products, and dialysis products.

開発領域

Infusion

We strive to provide a stable supply of high-functional and high-quality infusion solutions, including self-supporting soft bags developed to improve usability and visibility.

Injectables

Manufactured under sterile conditions, injectable products are used in medical settings where rapid and reliable therapeutic effects are required.

Dialysis Products

We aim to contribute to dialysis care by providing a range of dialysis products, including acetate-free dialysate, along with anticoagulants.

Contract Manufacturing

As a trusted partner supporting pharmaceutical manufacturing

Under strict manufacturing control, quality control, and hygiene control, we support a wide range of dosage forms with our advanced technical capabilities. We provide products that meet customer needs and support them through a comprehensive support system.

In addition to contract manufacturing of new drugs, generic drugs, biopharmaceuticals, and regenerative medicine-related products, we also offer contract development services, including analytical method development, investigational drug manufacturing, and regulatory application support.

Contract Manufacturing Capabilities: Products and Dosage Forms

Liquid Formulation Packaging Technology

Pre-filled Syringe Products (0.2mL、1mL、5mL)

Features	Filling equipment capable of handling small-volume, multi-product production Single-use lines are used to minimize the risk of contamination Aseptic filling with sterilizing filtration is used to accommodate a wide range of formulations
Syringe Sizes	0.5 mL to 5 mL syringes
Container Materials	Glass or plastic resin; no specific restrictions
Lot Scale	64 tubs
Pen injectors and auto-injectors	To be discussed on a case-by-case basis
Manufacturing Site	Saitama Plant

Vial Products (5mL、10mL、50mL、100mL)

Features	Vial washing and drying are performed in-house The filling area is equipped with a clean booth, enabling filling under aseptic conditions Final sterilization is performed with bioburden control to ensure sterility assurance
Vial Sizes	5 mL to 100 mL vials
Container Material	Glass
Manufacturing Site	Oigawa Plant

Single Bag Products (100mL、200mL、300mL、500mL)

Features	In-house film formation enables cost reduction, making this dosage form suitable for mass production. In addition to standard single-bag formats, formats equipped with a mixing/injection port can also be provided. Bag making, filling, and final packaging are performed on an integrated production line. Secondary packaging with gas-barrier outer packaging is available, with the option of including an oxygen absorber. Both final sterilization based on bioburden control and overkill sterilization are available for sterility assurance.
Bag Sizes	100mL／200mL／300mL／500mL bags
Container Material	Polyethylene
Manufacturing Site	Shimizu Plant Products with a mixing/injection port are manufactured at the Saitama Plant.

Standing Bag® Products (200mL、300mL、500mL)

Features	Standing Bag_®, a container that combines the advantages of both bottles and bags, is used. In-house film formation enables cost reduction. Bag making, filling, and final packaging are performed on an integrated production line. Secondary packaging is not available. Final sterilization based on bioburden control is performed for sterility assurance.
Bag Sizes	200mL／300mL／500mL bags
Container Material	Polyethylene
Manufacturing Site	Oigawa Plant

Liquid Formulation Packaging Technology

We support everything from formulation development to commercial production.

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Initial Consultation
Non-Disclosure Agreement (NDA)
Disclosure of product information by the client, including ingredients, quantities,manufacturing methods, production volume, and other details
Schedule Confirmation
Quotation Review

Quotation Presentation
（Development costs and transaction prices）

Development costs and transaction prices
Development services, including technology transfer, manufacturing process evaluation, prototyping, stability testing, and related activities
Regulatory application by the client
Commercial-scale validation and related activities